Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers

To provide protective immunity against circulating primary HIV-1 strains, a vaccine most likely has to induce broadly neutralizing antibodies to the HIV-1 envelope glycoprotein (Env) spike. Recombinant Env trimers such as the prototype BG505 SOSIP.664 that closely mimic the native Env spike can indu...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: de Taeye, Steven W., de la Peña, Alba Torrents, Vecchione, Andrea, Scutigliani, Enzo, Sliepen, Kwinten, Burger, Judith A., van der Woude, Patricia, Schorcht, Anna, Schermer, Edith E., van Gils, Marit J., LaBranche, Celia C., Montefiori, David C., Wilson, Ian A., Moore, John P., Ward, Andrew B., Sanders, Rogier W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798299/
https://ncbi.nlm.nih.gov/pubmed/29222332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000709
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