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Structural basis for molecular recognition of folic acid by folate receptors
Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind folate with high affinity to mediate cellular uptake of folate. Although expressed at very low levels in most tissues, folate receptors, especially FRα, are expressed at high levels in numerous cancers to meet...
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| Pubblicato in: | Nature |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5797940/ https://ncbi.nlm.nih.gov/pubmed/23851396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12327 |
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