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Structural basis for molecular recognition of folic acid by folate receptors

Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind folate with high affinity to mediate cellular uptake of folate. Although expressed at very low levels in most tissues, folate receptors, especially FRα, are expressed at high levels in numerous cancers to meet...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Chen, Chen, Ke, Jiyuan, Zhou, X Edward, Yi, Wei, Brunzelle, Joseph S., Li, Jun, Yong, Eu-Leong, Xu, H. Eric, Melcher, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797940/
https://ncbi.nlm.nih.gov/pubmed/23851396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12327
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