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Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes

Cytochromes P450s (P450s) catalyze oxygenation reactions via interactions with their redox partners. However, other proteins, particularly other P450s, also have been shown to form complexes that modulate P450 function. Previous studies showed that CYP1A2 and CYP2B4 form a complex when reconstituted...

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Veröffentlicht in:Drug Metab Dispos
Hauptverfasser: Connick, J. Patrick, Reed, James R., Backes, Wayne L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797933/
https://ncbi.nlm.nih.gov/pubmed/29233819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.078642
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