Decreased TESK1-mediated cofilin 1 phosphorylation in the jejunum of IBS-D patients may explain increased female predisposition to epithelial dysfunction

Disturbed intestinal epithelial barrier and mucosal micro-inflammation characterize irritable bowel syndrome (IBS). Despite intensive research demonstrating ovarian hormones modulation of IBS severity, there is still limited knowledge on the mechanisms underlying female predominance in this disorder...

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Publicado en:Sci Rep
Main Authors: Rodiño-Janeiro, Bruno K., Martínez, Cristina, Fortea, Marina, Lobo, Beatriz, Pigrau, Marc, Nieto, Adoración, González-Castro, Ana María, Salvo-Romero, Eloísa, Guagnozzi, Danila, Pardo-Camacho, Cristina, Iribarren, Cristina, Azpiroz, Fernando, Alonso-Cotoner, Carmen, Santos, Javier, Vicario, Maria
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797119/
https://ncbi.nlm.nih.gov/pubmed/29396473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20540-9
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