miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea

OBJECTIVE: Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) expression correlated with ultrastructural abnormalities of the epi...

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Dettagli Bibliografici
Pubblicato in:Gut
Autori principali: Martínez, Cristina, Rodiño-Janeiro, Bruno K, Lobo, Beatriz, Stanifer, Megan L, Klaus, Bernd, Granzow, Martin, González-Castro, Ana M, Salvo-Romero, Eloisa, Alonso-Cotoner, Carmen, Pigrau, Marc, Roeth, Ralph, Rappold, Gudrun, Huber, Wolfgang, González-Silos, Rosa, Lorenzo, Justo, de Torres, Inés, Azpiroz, Fernando, Boulant, Steeve, Vicario, María, Niesler, Beate, Santos, Javier
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2017
Soggetti:
Neurogastroenterology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561373/
https://ncbi.nlm.nih.gov/pubmed/28082316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-311477
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