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ФC31 Integrase-Mediated Isolation and Characterization of Novel Safe Harbors for Transgene Expression in the Pig Genome

Programmable nucleases have allowed the rapid development of gene editing and transgenics, but the technology still suffers from the lack of predefined genetic loci for reliable transgene expression and maintenance. To address this issue, we used ФC31 integrase to navigate the porcine genome and ide...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bi, Yanzhen, Hua, Zaidong, Ren, Hongyan, Zhang, Liping, Xiao, Hongwei, Liu, Ximei, Hua, Wenjun, Mei, Shuqi, Molenaar, Adrian, Laible, Götz, Zheng, Xinmin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796098/
https://ncbi.nlm.nih.gov/pubmed/29300364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19010149
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