Isozygous and selectable marker-free MSTN knockout cloned pigs generated by the combined use of CRISPR/Cas9 and Cre/LoxP

Predictable, clean genetic modification (GM) in livestock is important for reliable phenotyping and biosafety. Here we reported the generation of isozygous, functional myostatin (MSTN) knockout cloned pigs free of selectable marker gene (SMG) by CRISPR/Cas9 and Cre/LoxP. CRISPR/Cas9-mediated homolog...

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Publicado no:Sci Rep
Main Authors: Bi, Yanzhen, Hua, Zaidong, Liu, Ximei, Hua, Wenjun, Ren, Hongyan, Xiao, Hongwei, Zhang, Liping, Li, Li, Wang, Zhirui, Laible, Götz, Wang, Yan, Dong, Faming, Zheng, Xinmin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987667/
https://ncbi.nlm.nih.gov/pubmed/27530319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31729
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