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ФC31 Integrase-Mediated Isolation and Characterization of Novel Safe Harbors for Transgene Expression in the Pig Genome

Programmable nucleases have allowed the rapid development of gene editing and transgenics, but the technology still suffers from the lack of predefined genetic loci for reliable transgene expression and maintenance. To address this issue, we used ФC31 integrase to navigate the porcine genome and ide...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Autores principales: Bi, Yanzhen, Hua, Zaidong, Ren, Hongyan, Zhang, Liping, Xiao, Hongwei, Liu, Ximei, Hua, Wenjun, Mei, Shuqi, Molenaar, Adrian, Laible, Götz, Zheng, Xinmin
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796098/
https://ncbi.nlm.nih.gov/pubmed/29300364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19010149
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