Opposing roles of TGFβ and BMP signaling in prostate cancer development

SMAD4 constrains progression of Pten-null prostate cancer and serves as a common downstream node of transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFβ receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate canc...

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Detalles Bibliográficos
Publicado en:Genes Dev
Autores principales: Lu, Xin, Jin, Eun-Jung, Cheng, Xi, Feng, Shan, Shang, Xiaoying, Deng, Pingna, Jiang, Shan, Chang, Qing, Rahmy, Sharif, Chaudhary, Seema, Lu, Xuemin, Zhao, Ren, Wang, Y. Alan, DePinho, Ronald A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795781/
https://ncbi.nlm.nih.gov/pubmed/29352019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.307116.117
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