Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail

BACKGROUND: In a recently described probe drug cocktail for clinically relevant drug transporters containing digoxin, furosemide, metformin and rosuvastatin, mutual interactions were essentially absent except for increases in the systemic exposure of rosuvastatin. To optimize the cocktail, we furthe...

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Dades bibliogràfiques
Publicat a:Eur J Drug Metab Pharmacokinet
Autors principals: Stopfer, Peter, Giessmann, Thomas, Hohl, Kathrin, Sharma, Ashish, Ishiguro, Naoki, Taub, Mitchell E., Jungnik, Arvid, Gansser, Dietmar, Ebner, Thomas, Müller, Fabian
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2017
Matèries:
Original Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794840/
https://ncbi.nlm.nih.gov/pubmed/28685495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-017-0427-9
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