Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail

BACKGROUND: In a recently described probe drug cocktail for clinically relevant drug transporters containing digoxin, furosemide, metformin and rosuvastatin, mutual interactions were essentially absent except for increases in the systemic exposure of rosuvastatin. To optimize the cocktail, we furthe...

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Vydáno v:Eur J Drug Metab Pharmacokinet
Hlavní autoři: Stopfer, Peter, Giessmann, Thomas, Hohl, Kathrin, Sharma, Ashish, Ishiguro, Naoki, Taub, Mitchell E., Jungnik, Arvid, Gansser, Dietmar, Ebner, Thomas, Müller, Fabian
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2017
Témata:
Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794840/
https://ncbi.nlm.nih.gov/pubmed/28685495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-017-0427-9
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