Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail

BACKGROUND: In a recently described probe drug cocktail for clinically relevant drug transporters containing digoxin, furosemide, metformin and rosuvastatin, mutual interactions were essentially absent except for increases in the systemic exposure of rosuvastatin. To optimize the cocktail, we furthe...

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Bibliografiske detaljer
Udgivet i:Eur J Drug Metab Pharmacokinet
Main Authors: Stopfer, Peter, Giessmann, Thomas, Hohl, Kathrin, Sharma, Ashish, Ishiguro, Naoki, Taub, Mitchell E., Jungnik, Arvid, Gansser, Dietmar, Ebner, Thomas, Müller, Fabian
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2017
Fag:
Original Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794840/
https://ncbi.nlm.nih.gov/pubmed/28685495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-017-0427-9
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