Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail

BACKGROUND: In a recently described probe drug cocktail for clinically relevant drug transporters containing digoxin, furosemide, metformin and rosuvastatin, mutual interactions were essentially absent except for increases in the systemic exposure of rosuvastatin. To optimize the cocktail, we furthe...

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Dettagli Bibliografici
Pubblicato in:Eur J Drug Metab Pharmacokinet
Autori principali: Stopfer, Peter, Giessmann, Thomas, Hohl, Kathrin, Sharma, Ashish, Ishiguro, Naoki, Taub, Mitchell E., Jungnik, Arvid, Gansser, Dietmar, Ebner, Thomas, Müller, Fabian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2017
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Original Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794840/
https://ncbi.nlm.nih.gov/pubmed/28685495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-017-0427-9
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