Pharmacokinetic Evaluation of a Drug Transporter Cocktail Consisting of Digoxin, Furosemide, Metformin, and Rosuvastatin

This article reports the clinical investigation of a probe drug cocktail containing substrates of key drug transporters. Single oral doses of 0.25 mg digoxin (P‐gp), 5 mg furosemide (OAT1 and OAT3), 500 mg metformin (OCT2, MATE1, and MATE2‐K), and 10 mg rosuvastatin (OATP1B1, OATP1B3, and BCRP) were...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Stopfer, P, Giessmann, T, Hohl, K, Sharma, A, Ishiguro, N, Taub, ME, Zimdahl‐Gelling, H, Gansser, D, Wein, M, Ebner, T, Müller, F
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102573/
https://ncbi.nlm.nih.gov/pubmed/27256812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.406
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