Optimization of a drug transporter probe cocktail: potential screening tool for transporter‐mediated drug–drug interactions

AIMS: Previous pharmacokinetic characterization of a transporter probe cocktail containing digoxin (P‐gp), furosemide (OAT1, OAT3), metformin (OCT2, MATE1, MATE2‐K) and rosuvastatin (OATP1B1, OATP1B3, BCRP) in healthy subjects showed increases in rosuvastatin systemic exposure compared to rosuvastat...

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Publicado en:Br J Clin Pharmacol
Autores principales: Stopfer, Peter, Giessmann, Thomas, Hohl, Kathrin, Hutzel, Sabine, Schmidt, Sven, Gansser, Dietmar, Ishiguro, Naoki, Taub, Mitchell E., Sharma, Ashish, Ebner, Thomas, Müller, Fabian
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089804/
https://ncbi.nlm.nih.gov/pubmed/29665130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13609
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