Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation

Nuclear factor of activated T cells (NFAT) transcription factors are required for induction of T-cell cytokine production and effector function. Although it is known that activation via the T-cell antigen receptor (TCR) results in 2 critical steps, calcineurin-mediated NFAT1 dephosphorylation and NF...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Alam, Muhammad S., Gaida, Matthias M., Debnath, Subrata, Tagad, Harichandra D., Miller Jenkins, Lisa M., Appella, Ettore, Rahman, M. Jubayer, Ashwell, Jonathan D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794172/
https://ncbi.nlm.nih.gov/pubmed/29357353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2004111
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