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T Cell Receptor-mediated Activation of p38α by Mono-phosphorylation of the Activation Loop Results in Altered Substrate Specificity

p38 MAPKs are typically activated by upstream MAPK kinases that phosphorylate a Thr-X-Tyr motif in the activation loop. An exception is the T cell antigen receptor signaling pathway, which bypasses the MAPK cascade and activates p38α and p38β by phosphorylation of Tyr-323 and subsequent autophosphor...

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Detalhes bibliográficos
Main Authors: Mittelstadt, Paul R., Yamaguchi, Hiroshi, Appella, Ettore, Ashwell, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708844/
https://ncbi.nlm.nih.gov/pubmed/19324872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901004200
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