An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract

Oxidative DNA damage and base excision repair (BER) play important roles in modulating trinucleotide repeat (TNR) instability that is associated with human neurodegenerative diseases and cancer. We have reported that BER of base lesions can lead to TNR instability. However, it is unknown if modifica...

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Publicado en:PLoS One
Main Authors: Beaver, Jill M., Lai, Yanhao, Rolle, Shantell J., Weng, Liwei, Greenberg, Marc M., Liu, Yuan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794147/
https://ncbi.nlm.nih.gov/pubmed/29389977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192148
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