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An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract
Oxidative DNA damage and base excision repair (BER) play important roles in modulating trinucleotide repeat (TNR) instability that is associated with human neurodegenerative diseases and cancer. We have reported that BER of base lesions can lead to TNR instability. However, it is unknown if modifica...
Shranjeno v:
| izdano v: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5794147/ https://ncbi.nlm.nih.gov/pubmed/29389977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192148 |
| Oznake: |
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