Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk

The high-risk pedigree (HRP) design is an established strategy to discover rare, highly-penetrant, Mendelian-like causal variants. Its success, however, in complex traits has been modest, largely due to challenges of genetic heterogeneity and complex inheritance models. We describe a HRP strategy th...

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Vydáno v:PLoS Genet
Hlavní autoři: Waller, Rosalie G., Darlington, Todd M., Wei, Xiaomu, Madsen, Michael J., Thomas, Alun, Curtin, Karen, Coon, Hilary, Rajamanickam, Venkatesh, Musinsky, Justin, Jayabalan, David, Atanackovic, Djordje, Rajkumar, S. Vincent, Kumar, Shaji, Slager, Susan, Middha, Mridu, Galia, Perrine, Demangel, Delphine, Salama, Mohamed, Joseph, Vijai, McKay, James, Offit, Kenneth, Klein, Robert J., Lipkin, Steven M., Dumontet, Charles, Vachon, Celine M., Camp, Nicola J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794067/
https://ncbi.nlm.nih.gov/pubmed/29389935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007111
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