Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk

The high-risk pedigree (HRP) design is an established strategy to discover rare, highly-penetrant, Mendelian-like causal variants. Its success, however, in complex traits has been modest, largely due to challenges of genetic heterogeneity and complex inheritance models. We describe a HRP strategy th...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Waller, Rosalie G., Darlington, Todd M., Wei, Xiaomu, Madsen, Michael J., Thomas, Alun, Curtin, Karen, Coon, Hilary, Rajamanickam, Venkatesh, Musinsky, Justin, Jayabalan, David, Atanackovic, Djordje, Rajkumar, S. Vincent, Kumar, Shaji, Slager, Susan, Middha, Mridu, Galia, Perrine, Demangel, Delphine, Salama, Mohamed, Joseph, Vijai, McKay, James, Offit, Kenneth, Klein, Robert J., Lipkin, Steven M., Dumontet, Charles, Vachon, Celine M., Camp, Nicola J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794067/
https://ncbi.nlm.nih.gov/pubmed/29389935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007111
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