Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk

The high-risk pedigree (HRP) design is an established strategy to discover rare, highly-penetrant, Mendelian-like causal variants. Its success, however, in complex traits has been modest, largely due to challenges of genetic heterogeneity and complex inheritance models. We describe a HRP strategy th...

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Bibliografiset tiedot
Julkaisussa:PLoS Genet
Päätekijät: Waller, Rosalie G., Darlington, Todd M., Wei, Xiaomu, Madsen, Michael J., Thomas, Alun, Curtin, Karen, Coon, Hilary, Rajamanickam, Venkatesh, Musinsky, Justin, Jayabalan, David, Atanackovic, Djordje, Rajkumar, S. Vincent, Kumar, Shaji, Slager, Susan, Middha, Mridu, Galia, Perrine, Demangel, Delphine, Salama, Mohamed, Joseph, Vijai, McKay, James, Offit, Kenneth, Klein, Robert J., Lipkin, Steven M., Dumontet, Charles, Vachon, Celine M., Camp, Nicola J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794067/
https://ncbi.nlm.nih.gov/pubmed/29389935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007111
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