Exogenous insulin infusion can decrease atherosclerosis in diabetic rodents by improving lipids, inflammation, and endothelial function

OBJECTIVE: To evaluate whether exogenously-induced hyperinsulinemia may increase the development of atherosclerosis. APPROACH & RESULTS: Hyperinsulinemia, induced by exogenous insulin implantation in high fat fed (60% fat HFD) ApoE(−/−) mice, exhibited insulin resistance, hyperglycemia and hyper...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Park, Kyoungmin, Li, Qian, Evcimen, Net Daş, Rask-Madsen, Christian, Maeda, Yasutaka, Maddaloni, Ernesto, Yokomizo, Hisashi, Shinjo, Takanori, St-Louis, Ronald, Fu, Jialin, Gordin, Daniel, Khamaisi, Mogher, Pober, David, Keenan, Hillary, King, George L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791542/
https://ncbi.nlm.nih.gov/pubmed/29162603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310291
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