Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance

The effect of enhancing insulin’s actions in endothelial cells (ECs) to improve angiogenesis and wound healing was studied in obesity and diabetes. Insulin receptor substrate 1 (IRS1) was overexpressed in ECs using the VE-cadherin promoter to create ECIRS1 TG mice, which elevated pAkt activation and...

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Bibliographic Details
Published in:Diabetes
Main Authors: Katagiri, Sayaka, Park, Kyoungmin, Maeda, Yasutaka, Rao, Tata Nageswara, Khamaisi, Mogher, Li, Qian, Yokomizo, Hisashi, Mima, Akira, Lancerotto, Luca, Wagers, Amy, Orgill, Dennis P., King, George L.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2016
Subjects:
Complications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001189/
https://ncbi.nlm.nih.gov/pubmed/27217486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1721
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