Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance

The effect of enhancing insulin’s actions in endothelial cells (ECs) to improve angiogenesis and wound healing was studied in obesity and diabetes. Insulin receptor substrate 1 (IRS1) was overexpressed in ECs using the VE-cadherin promoter to create ECIRS1 TG mice, which elevated pAkt activation and...

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Vydáno v:Diabetes
Hlavní autoři: Katagiri, Sayaka, Park, Kyoungmin, Maeda, Yasutaka, Rao, Tata Nageswara, Khamaisi, Mogher, Li, Qian, Yokomizo, Hisashi, Mima, Akira, Lancerotto, Luca, Wagers, Amy, Orgill, Dennis P., King, George L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2016
Témata:
Complications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001189/
https://ncbi.nlm.nih.gov/pubmed/27217486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1721
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