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Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation

Monoclonal antibodies (mAbs) have been developed as therapeutics, especially for the treatment of cancer, inflammation, and infectious diseases. Because the glycosylation of mAbs in the Fc region influences their interaction with effector cells that kill antibody-targeted cells, and the current meth...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Liu, Chiu-Ping, Tsai, Tsung-I., Cheng, Ting, Shivatare, Vidya S., Wu, Chung-Yi, Wong, Chi-Huey
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789950/
https://ncbi.nlm.nih.gov/pubmed/29311294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718172115
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