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Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation

Monoclonal antibodies (mAbs) have been developed as therapeutics, especially for the treatment of cancer, inflammation, and infectious diseases. Because the glycosylation of mAbs in the Fc region influences their interaction with effector cells that kill antibody-targeted cells, and the current meth...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Liu, Chiu-Ping, Tsai, Tsung-I., Cheng, Ting, Shivatare, Vidya S., Wu, Chung-Yi, Wong, Chi-Huey
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789950/
https://ncbi.nlm.nih.gov/pubmed/29311294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718172115
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