Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

The adult mouse subependymal zone provides a niche for mammalian neural stem cells (NSCs). However, the molecular signature, self-renewal potential, and fate behavior of NSCs remain poorly defined. Here we propose a model in which the fate of active NSCs is coupled to the total number of neighboring...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Basak, Onur, Krieger, Teresa G., Muraro, Mauro J., Wiebrands, Kay, Stange, Daniel E., Frias-Aldeguer, Javier, Rivron, Nicolas C., van de Wetering, Marc, van Es, Johan H., van Oudenaarden, Alexander, Simons, Benjamin D., Clevers, Hans
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789932/
https://ncbi.nlm.nih.gov/pubmed/29311336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715911114
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