Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer’s disease model

BACKGROUND: Oligomeric forms of amyloid-β (Aβ) and tau are increasing being recognized as key toxins in the pathogenesis of Alzheimer’s disease (AD). METHODS: We developed a novel monoclonal antibody (mAb), GW-23B7, that recognizes β-sheet secondary structure on pathological oligomers of neurodegene...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Goñi, Fernando, Martá-Ariza, Mitchell, Herline, Krystal, Peyser, Daniel, Boutajangout, Allal, Mehta, Pankaj, Drummond, Eleanor, Prelli, Frances, Wisniewski, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789573/
https://ncbi.nlm.nih.gov/pubmed/29378642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-018-0337-3
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