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Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases

We describe a novel approach to produce conformational monoclonal antibodies selected to specifically react with the β-sheet secondary structure of pathological oligomeric conformers, characteristic of many neurodegenerative diseases. Contrary to past and current efforts, we utilize a mammalian non-...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Goñi, Fernando, Martá-Ariza, Mitchell, Peyser, Daniel, Herline, Krystal, Wisniewski, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575137/
https://ncbi.nlm.nih.gov/pubmed/28852189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10393-z
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