Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models

BACKGROUND: Central to the pathogenesis of Alzheimer’s disease (AD) and many other neurodegenerative diseases is the conformational change of a normal self-protein into toxic oligomeric species and amyloid deposits. None of these disorders have an effective therapy, but immunization approaches hold...

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Main Authors: Goñi, Fernando, Herline, Krystal, Peyser, Daniel, Wong, Kinlung, Ji, Yong, Sun, Yanjie, Mehta, Pankaj, Wisniewski, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878790/
https://ncbi.nlm.nih.gov/pubmed/24330773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-150
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