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Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum

Aβ oligomers (AβOs) are crucially involved in Alzheimer’s Disease (AD). However, the lack of selective approaches for targeting these polymorphic Aβ assemblies represents a major hurdle in understanding their biosynthesis, traffic and actions in living cells. Here, we established a subcellularly loc...

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Autori principali: Meli, Giovanni, Lecci, Agnese, Manca, Annalisa, Krako, Nina, Albertini, Valentina, Benussi, Luisa, Ghidoni, Roberta, Cattaneo, Antonino
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050278/
https://ncbi.nlm.nih.gov/pubmed/24861166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4867
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