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Blocking the Apolipoprotein E/Amyloid β Interaction in Triple Transgenic Mice Ameliorates Alzheimer’s Disease Related Amyloid β and Tau Pathology

Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late-onset Alzheimer’s disease (AD). Studies have shown that the binding between apoE and amyloid-β (Aβ) peptides occurs at residues 244–272 of apoE and residues 12–28 of Aβ. ApoE4 has been...

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Библиографические подробности
Главные авторы: Liu, Shan, Breitbart, Ariel, Sun, Yanjie, Mehta, Pankaj D., Boutajangout, Allal, Scholtzova, Henrieta, Wisniewski, Thomas
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946231/
https://ncbi.nlm.nih.gov/pubmed/24117759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12484
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