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Blocking the apolipoprotein E/amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease

The amyloid-β (Aβ) cascade hypothesis of Alzheimer's disease (AD) maintains that accumulation of Aβ peptide constitutes a critical event in the early disease pathogenesis. The direct binding between Aβ and apolipoprotein E (apoE) is an important factor implicated in both Aβ clearance and its de...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sadowski, Martin J., Pankiewicz, Joanna, Scholtzova, Henrieta, Mehta, Pankaj D., Prelli, Frances, Quartermain, David, Wisniewski, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1654132/
https://ncbi.nlm.nih.gov/pubmed/17116874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604011103
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