Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer’s disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12-28 of Aβ and this binding modulates Aβ accumulation a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liu, Shan, Park, Shinae, Allington, Grant, Prelli, Frances, Sun, Yanjie, Martá-Ariza, Mitchell, Scholtzova, Henrieta, Biswas, Goutam, Brown, Bernard, Verghese, Philip B., Mehta, Pankaj D., Kwon, Yong-Uk, Wisniewski, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556019/
https://ncbi.nlm.nih.gov/pubmed/28808293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08604-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados