Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer’s disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12-28 of Aβ and this binding modulates Aβ accumulation a...

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Publicat a:Sci Rep
Autors principals: Liu, Shan, Park, Shinae, Allington, Grant, Prelli, Frances, Sun, Yanjie, Martá-Ariza, Mitchell, Scholtzova, Henrieta, Biswas, Goutam, Brown, Bernard, Verghese, Philip B., Mehta, Pankaj D., Kwon, Yong-Uk, Wisniewski, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556019/
https://ncbi.nlm.nih.gov/pubmed/28808293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08604-8
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