Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer's Disease

Many neurodegenerative diseases are characterized by the conformational change of normal self-proteins into amyloidogenic, pathological conformers, which share structural properties such as high β-sheet content and resistance to degradation. The most common is Alzheimer's disease (AD) where the...

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Detalhes bibliográficos
Main Authors: Goñi, Fernando, Prelli, Frances, Ji, Yong, Scholtzova, Henrieta, Yang, Jing, Sun, Yanjie, Liang, Feng-Xia, Kascsak, Regina, Kascsak, Richard, Mehta, Pankaj, Wisniewski, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954195/
https://ncbi.nlm.nih.gov/pubmed/20967130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013391
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