Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors

Multipotent hematopoietic progenitors must acquire thymus-homing capacity to initiate T lymphocyte development. Despite its importance, the transcriptional program underlying this process remains elusive. Cbfβ forms transcription factor complexes with Runx proteins, and here we show that Cbfβ2, enco...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Tenno, Mari, Kojo, Satoshi, Lawir, Divine-Fondzenyuy, Hess, Isabell, Shiroguchi, Katsuyuki, Ebihara, Takashi, Endo, Takaho A., Muroi, Sawako, Satoh, Rumi, Kawamoto, Hiroshi, Boehm, Thomas, Taniuchi, Ichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789415/
https://ncbi.nlm.nih.gov/pubmed/29343500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171221
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