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Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
An intronic silencer, S4, in the Cd4 gene has been shown to be responsible for the helper-lineage-specific expression of CD4; S4 requires Runx complex binding to exert its silencer function against the enhancer-mediated Cd4 activation by modulating the epigenetic state of the Cd4 gene. Here we ident...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6125603/ https://ncbi.nlm.nih.gov/pubmed/30185787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05803-3 |
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