Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells

Temporal down-regulation of the CD8 co-receptor after receiving positive-selection signals has been proposed to serve as an important determinant to segregate helper versus cytotoxic lineages by generating differences in the duration of TCR signaling between MHC-I and MHC-II selected thymocytes. By...

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Vydáno v:Life Sci Alliance
Hlavní autoři: Kojo, Satoshi, Ohno-Oishi, Michiko, Wada, Hisashi, Nieke, Sebastian, Seo, Wooseok, Muroi, Sawako, Taniuchi, Ichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Life Science Alliance LLC 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985454/
https://ncbi.nlm.nih.gov/pubmed/31980555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000642
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