Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation

Th9 cells are prominently featured in allergic lung inflammation, but the mechanism that regulates IL-9 induction in T helper cells remains poorly defined. Here we demonstrate that formation of super-enhancers (SEs) is critical in robust induction of IL-9 and that assembly of the Il9 SEs in Th cells...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Xiao, Xiang, Fan, Yihui, Li, Junhui, Zhang, Xiaolong, Lou, Xiaohua, Dou, Yaling, Shi, Xiaomin, Lan, Peixiang, Xiao, Yue, Minze, Laurie, Li, Xian Chang
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2018
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789412/
https://ncbi.nlm.nih.gov/pubmed/29339447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170928
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