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Conformation-dependent recognition of mutant HTT (huntingtin) proteins by selective autophagy
Protein misfolding is the common theme for neurodegenerative disorders including Huntington disease (HD), which is mainly caused by cytotoxicity of the mutant HTT (huntingtin) protein (mHTT). The soluble mHTT has an expanded polyglutamine (polyQ) stretch that may adopt multiple conformations, among...
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| Publicado no: | Autophagy |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5788554/ https://ncbi.nlm.nih.gov/pubmed/28976800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1382783 |
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