HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner

Huntington’s Disease (HD) is a monogenetic neurodegenerative disorder mainly caused by the cytotoxicity of the mutant HTT protein (mHTT) encoded by the mutant HTT gene. Lowering HTT mRNA has been extensively studied as a potential therapeutic strategy, but how its level is regulated endogenously has...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Zhao, Quan, Li, Chen, Yu, Meng, Sun, Yimin, Wang, Jian, Ma, Lixiang, Sun, Xiaoli, Lu, Boxun
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237150/
https://ncbi.nlm.nih.gov/pubmed/31928144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1712894
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