Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models

Most neurodegenerative disorders are associated with accumulation of disease-relevant proteins. Among them, Huntington disease (HD) is of particular interest because of its monogenetic nature. HD is mainly caused by cytotoxicity of the defective protein encoded by the mutant Huntingtin gene (HTT). T...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Yu, Meng, Fu, Yuhua, Liang, Yijiang, Song, Haikun, Yao, Yao, Wu, Peng, Yao, Yuwei, Pan, Yuyin, Wen, Xue, Ma, Lixiang, Hexige, Saiyin, Ding, Yu, Luo, Shouqing, Lu, Boxun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717400/
https://ncbi.nlm.nih.gov/pubmed/29151587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.113
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