ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells

Lysosomal autophagy inhibitors (LAI) such as hydroxychloroquine (HCQ) have significant activity in a subset of cancer cell lines. LAIs are being evaluated in cancer clinical trials, but genetic determinants of sensitivity to LAIs are unknown, making it difficult to predict which tumors would be most...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Autophagy
Main Authors: Piao, Shengfu, Ojha, Rani, Rebecca, Vito W., Samanta, Arabinda, Ma, Xiao-hong, Mcafee, Quentin, Nicastri, Michael C., Buckley, Meghan, Brown, Eric, Winkler, Jeffrey D., Gimotty, Phyllis A., Amaravadi, Ravi K.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2017
Teme:
Research Paper-Basic Science
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788553/
https://ncbi.nlm.nih.gov/pubmed/28981387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1377377
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