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Lys05: A new lysosomal autophagy inhibitor
Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared wi...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442884/ https://ncbi.nlm.nih.gov/pubmed/22878685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.20958 |
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