Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

Autophagy is a lysosome-dependent degradative process that protects cancer cells from multiple stresses. In preclinical models, autophagy inhibition with chloroquine (CQ) derivatives augments the efficacy of many anticancer therapies, but CQ has limited activity as a single agent. Clinical trials ar...

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Detalhes bibliográficos
Main Authors: McAfee, Quentin, Zhang, Zhihui, Samanta, Arabinda, Levi, Samuel M., Ma, Xiao-Hong, Piao, Shengfu, Lynch, John P., Uehara, Takeshi, Sepulveda, Antonia R., Davis, Lisa E., Winkler, Jeffrey D., Amaravadi, Ravi K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361415/
https://ncbi.nlm.nih.gov/pubmed/22566612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118193109
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