PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma

New strategies are needed to enhance the efficacy of anti–programmed cell death protein antibody (anti–PD-1 Ab) in cancer. Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of chloroquine derivatives like hydroxychloroquine (HCQ), enhances the antitumor efficacy of an...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Sharma, Gaurav, Ojha, Rani, Noguera-Ortega, Estela, Rebecca, Vito W., Attanasio, John, Liu, Shujing, Piao, Shengfu, Lee, Jennifer J., Nicastri, Michael C., Harper, Sandra L., Ronghe, Amruta, Jain, Vaibhav, Winkler, Jeffrey D., Speicher, David W., Mastio, Jerome, Gimotty, Phyllis A., Xu, Xiaowei, Wherry, E. John, Gabrilovich, Dmitry I., Amaravadi, Ravi K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526447/
https://ncbi.nlm.nih.gov/pubmed/32780726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133225
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