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Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells
DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1). DQ661 has in vivo activity in immunocompetent mouse models of cancer...
Kaydedildi:
| Yayımlandı: | Mol Cell Oncol |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Taylor & Francis
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5791860/ https://ncbi.nlm.nih.gov/pubmed/29404393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1395504 |
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