GSK3β-dependent cyclin D1 and cyclin E1 degradation is indispensable for NVP-BEZ235 induced G0/G1 arrest in neuroblastoma cells

Cyclin D1 and cyclin E1, as vital regulatory factors of G1-S phase cell cycle progression, are frequently constitutive expressed and associated with pathogenesis and tumorigenesis in most human cancers and they have been regarded as promising targets for cancer therapy. In this study, we established...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Liu, Shan-Ling, Liu, Zhen, Zhang, Li-Di, Zhu, Han-Qing, Guo, Jia-Hui, Zhao, Mei, Wu, Ying-Li, Liu, Feng, Gao, Feng-Hou
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788431/
https://ncbi.nlm.nih.gov/pubmed/28980866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1383577
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