GSK3β-dependent cyclin D1 and cyclin E1 degradation is indispensable for NVP-BEZ235 induced G0/G1 arrest in neuroblastoma cells

Cyclin D1 and cyclin E1, as vital regulatory factors of G1-S phase cell cycle progression, are frequently constitutive expressed and associated with pathogenesis and tumorigenesis in most human cancers and they have been regarded as promising targets for cancer therapy. In this study, we established...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Liu, Shan-Ling, Liu, Zhen, Zhang, Li-Di, Zhu, Han-Qing, Guo, Jia-Hui, Zhao, Mei, Wu, Ying-Li, Liu, Feng, Gao, Feng-Hou
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788431/
https://ncbi.nlm.nih.gov/pubmed/28980866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1383577
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