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SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitors
Bromodomain and extra-terminal (BET) proteins are frequently overexpressed in various human cancers, therefore have been clinically pursed as attractive therapeutic anti-cancer targets. However, relatively little is known about the mechanism(s) underlying aberrant BET overexpression in human cancers...
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| Vydáno v: | Cell Cycle |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Taylor & Francis
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5788415/ https://ncbi.nlm.nih.gov/pubmed/29108467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1388973 |
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